WebNov 26, 2024 · A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. The macrolactone core of 3 ... WebNov 2, 2024 · The synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being …

Macrocyclic Core of Salarin C: Synthesis and Oxidation

WebThe synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being replaced by alkene … WebNov 12, 2013 · In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS data and Mosher’s … breaking news today school shooting

Studies toward the Total Synthesis of the Marine Macrolide Salarin C …

WebFeb 1, 2012 · Salarin B's structure (2), based on the structure of salarin J (10), is now amended to also incorporate the C-14 to -17 THF ring system. All compounds were … WebDideoxysalarin C 133, a potential intermediate for the synthesis of the marine natural macrolide salarin C (08TL4355), was synthesized through a convergent strategy by Altmann and Schrof. This structurally intriguing compound contains a trisubstituted oxazole ring embedded in an 18-membered macrolactone cycle. WebA convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described.The macrolactone core of 3 was assembled by Suzuki coupling between alkyl iodide 9 and vinyl iodide 8 and Shiina macrolactonization as key transformations. All macrocyclic intermediates were … cost of handmade custom bricks