Galectin-4 is a protein that in humans is encoded by the LGALS4 gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer. The 323-amino acid LGALS4 … See more Gal 4 belongs to the family of galectin. Among various structure of galectins like dimeric, tandem or chimera, Gal-4 is tandem in its structure, so they contains at least two distinct carbohydrate recognising domains (CRD) … See more Recommended name:Galectin-4, Short name: Gal-4 Alternative name(s): See more Gal-4 has binding ability with high affinity to lipid rafts suggesting a role in protein delivery to cells Plus they can … See more • Huflejt ME, Jordan ET, Gitt MA, et al. (1997). "Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion" See more Gal-4 is generally found in stomach and intestine. See more Gal-4 and cancer Gal-4 which has been detected in many cancer has involved in association with the development and sequence of pancreatic carcinoma, hepatocellular carcinoma, Colorectal cancer (CRC), breast carcinoma, gastric cancer, … See more WebIn particular, galectin-4 is found to cover these unmyelinated segments, colocalize with contactin-1 and inhibit oligodendrocytes from depositing myelin on these segments (Díez-Revuelta et al., 2024). Additionally, galectin-4 is secreted by neurons and inhibits the maturation of oligodendrocytes (Stancic et al., 2012). In contrast, astrocytes ...
Galectin 2 - an overview ScienceDirect Topics
Webpassing the carbohydrate-binding site [2]. Galectin-3 exerts a diversity of functions, depending on its subcellular localization. Cell surface galectin-3 med-iates cell–cell and cell–matrix interaction [3,4], while nuclear galectin-3 is involved in pre-mRNA splicing [5]. Cytoplasmic galectin-3 works as an WebGalectin-4, in particular, organizes lipid rafts and membrane microdomains consisting mainly of glycosphingolipids and cholesterol in the outer leaflet of the plasma membrane lipid bilayer. Such remodeling may also support changes in tight junction structure during salinity acclimation. Collectively, these data support the notion that acute ... is kreese johnny\\u0027s father
Cytosolic galectin-4 enchains bacteria, restricts their motility, and ...
WebGalectin-3 and beta-catenin are associated with a poor prognosis in serous epithelial ovarian cancer Yunyun Liu,1,2,* Lingling Xie,1,2,* Dongyan Wang,1 Da Li,1 Guocai Xu,1 … WebMar 1, 2002 · Galectin-4 has been found to be localized in the epithelium of the alimentary tract, including oral mucosa, esophagus, and intestinal mucosa (Chiu et al., 1994; Danielsen and Deurs, 1997). Chiu et al. found that galectin-4 in porcine oral and upper esophageal epithelium is water-insoluble as a component of adherens junction complexes. WebTandem galectins include galectin-4, -6, -8, -9 and -12. The final galectin is galectin-3 which is the only galectin found in the chimera category in vertebrates. Galectin-3 has … is kreekcraft really bald